A Validated LC-MS/MS Method for Simultaneous Determination of Six Aconitum Alkaloids and Seven Ginsenosides in Rat Plasma and Application to Pharmacokinetics of Shen-Fu Prescription

Table 1

Mass spectra properties of the compounds and IS.

Compounds	Precursor Ion (m/z)	Product Ion (m/z)	Frag. (V)	C.E. (V)
AC	646.4	586.3	240	35
MA	632.3	572.2	200	35
HA	616.3	556.2	175	35
BAC	604.3	105.0	140	60
BMA	590.3	105.0	240	60
BHA	574.3	105.0	240	60
Rb1	1131.6	364.9	380	70
Rb2	1101.6	335.0	370	65
Rc	1101.6	335.0	360	65
Rd	969.6	789.5	350	55
Re	969.6	789.5	340	45
Rf	823.5	365.1	320	55
Rg1	823.5	643.4	310	40
Psoralen (IS)	187.0	131.1	115	25