(+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer

Figure 6

8 M (+)-UA modulated c-KIT expression and SCF-mediated activation of PKC-A and c-KIT. (a) Western blot: (1) the treatment of HCT116 cells with 8 μM (+)-UA for 24 and 48 hours attenuated SCF-induced upregulation of p-PKC-A; (2) the treatment of HCT116 cells with 8 μM (+)-UA for 48 hours not only reversed SCF-induced upregulation of p-c-KIT but also mediated downregulation of c-KIT. (b) Quantitative analysis: , , , , and , versus DSMO; , , , , , , and , versus SCF.

(a)

(b)