(+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer

Figure 7

8 M of (+)-UA induced autophagic degradation of c-KIT. (a) Western blot: the treatment of HCT116 cells with 8 μM of (+)-UA for 48 h not only attenuated SCF-induced upregulation of p-c-KIT but also downregulated c-KIT, which were rescued by silencing of ATG5. (b) Quantitative analysis: , , , and , versus scramble RNA; , and , versus SCF; , , and , versus SCF + (+)-UA.

(a)

(b)