Hydroethanolic Extracts of Erigeron floribundus and Azadirachta indica Reduced Plasmodium berghei Parasitemia in Balb/c Mice

Table 4

Body and organ weights of rats subjected to subacute toxicity assessment of the hydroethanolic extracts of E. floribundus and A. indica.


Groups	Body weight (g) ± SD
Groups	Day 0	Day 7	Day 14	Day 21	Day 28

*(A) Rats treated with HEEF*
Control	123.3±9.1	127.8±8.8	131.8±9.2	136.8±8.8	143.5±9.5
60 mg/kg	123.3 ± 10.3	126.3 ± 9.7	129.8 ± 9.6	131.8 ± 9.9	134.7±10.2
120 mg/kg	123.3 ± 8.8	126.3 ± 9.0	129.7 ± 11.5	130.3 ± 8.2	133.0±7.7
240 mg/kg	123.0 ± 13.1	126.4 ± 12.5	130.4 ± 8.6	132.0±10.7	134.2±10.6

Groups	Organ weight (g) ± SD
Groups	Liver	Heart	Kidneys	Lungs	Spleen

Control	5.72 ± 0.66	0.62 ± 0.05	1.28 ± 0.13	1.16 ± 0.11	0.78 ± 0.19
60 mg/kg	5.15 ± 0.58	0.60 ± 0.08	1.26 ± 0.13	1.51 ± 0.65	0.80 ± 0.14
120 mg/kg	4.54 ± 1.46	0.54 ± 0.05	1.21 ± 0.09	1.39 ± 0.36	0.70 ± 0.15
240 mg/kg	5.16 ± 0.32	0.52 ± 0.06	1.17 ± 0.04	1.40 ± 0.53	0.79 ± 0.19

Groups	Body weight (g) ± SD
Groups	Day 0	Day 7	Day 14	Day 21	Day 28

*(B) Rats treated with HEAI*
Control	123.3 ± 9.11	127.8 ± 8.8	131.8 ± 9.2	136.8 ± 8.8	143.5 ± 9.5
75 mg/kg	123.2 ± 15.3	127.0 ± 15.0	130.0 ± 14.5	136.6 ± 13.7	139.3± 4.6
150 mg/kg	123.5 ± 10.2	128.0 ± 10.4	131.5 ± 9.4	136.0 ± 9.3	141.0±10.0
300 mg/kg	122.7 ± 5.8	126.5 ± 5.5	130.0 ± 5.8	133.7 ± 6.3	137.2 ± 6.5

Groups	Organ weight (g) ± SD
Groups	Liver	Heart	Kidneys	Lungs	Spleen

Control	5.72 ± 0.66	0.62 ± 0.05	1.28 ± 0.13	1.16 ± 0.11	0.78 ± 0.19
75 mg/kg	5.65 ± 0.58	0.56 ± 0.06	1.25 ± 0.06	1.09 ± 0.11	0.81 ± 0.13
150 mg/kg	5.93 ± 0.75	0.55 ± 0.05	1.33 ± 0.10	1.25 ± 0.37	0.74 ± 0.11
300 mg/kg	5.08 ± 0.37	0.54 ± 0.04	1.22 ± 0.06	1.37 ± 0.25	0.86 ± 0.44

Mice were administered with 60, 120, and 240mg/kg doses of HEEF, with 75, 150, and 300mg/kg doses of HEAI for 28 days, and mean body weight and organ weight were recorded before the treatment (day 0) and on days 7, 14, 21, and 28. The control group received 200 µL of distilled water.

Evidence-Based Complementary and Alternative Medicine

Hydroethanolic Extracts of Erigeron floribundus and Azadirachta indica Reduced Plasmodium berghei Parasitemia in Balb/c Mice

Table 4