Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 4

Research Article

Hydroethanolic Extracts of Erigeron floribundus and Azadirachta indica Reduced Plasmodium berghei Parasitemia in Balb/c Mice

Table 4

Body and organ weights of rats subjected to subacute toxicity assessment of the hydroethanolic extracts of E. floribundus and A. indica.

GroupsBody weight (g) ± SD
Day 0Day 7Day 14Day 21Day 28

(A) Rats treated with HEEF
Control123.3±9.1127.8±8.8131.8±9.2136.8±8.8143.5±9.5
60 mg/kg123.3 ± 10.3126.3 ± 9.7129.8 ± 9.6131.8 ± 9.9134.7±10.2
120 mg/kg123.3 ± 8.8126.3 ± 9.0129.7 ± 11.5130.3 ± 8.2133.0±7.7
240 mg/kg123.0 ± 13.1126.4 ± 12.5130.4 ± 8.6132.0±10.7134.2±10.6

GroupsOrgan weight (g) ± SD
LiverHeartKidneysLungsSpleen

Control5.72 ± 0.660.62 ± 0.051.28 ± 0.131.16 ± 0.110.78 ± 0.19
60 mg/kg5.15 ± 0.580.60 ± 0.081.26 ± 0.131.51 ± 0.650.80 ± 0.14
120 mg/kg4.54 ± 1.460.54 ± 0.051.21 ± 0.091.39 ± 0.360.70 ± 0.15
240 mg/kg5.16 ± 0.320.52 ± 0.061.17 ± 0.041.40 ± 0.530.79 ± 0.19

GroupsBody weight (g) ± SD
Day 0Day 7Day 14Day 21Day 28

(B) Rats treated with HEAI
Control123.3 ± 9.11127.8 ± 8.8131.8 ± 9.2136.8 ± 8.8143.5 ± 9.5
75 mg/kg123.2 ± 15.3127.0 ± 15.0130.0 ± 14.5136.6 ± 13.7139.3± 4.6
150 mg/kg123.5 ± 10.2128.0 ± 10.4131.5 ± 9.4136.0 ± 9.3141.0±10.0
300 mg/kg122.7 ± 5.8126.5 ± 5.5130.0 ± 5.8133.7 ± 6.3137.2 ± 6.5

GroupsOrgan weight (g) ± SD
LiverHeartKidneysLungsSpleen

Control5.72 ± 0.660.62 ± 0.051.28 ± 0.131.16 ± 0.110.78 ± 0.19
75 mg/kg5.65 ± 0.580.56 ± 0.061.25 ± 0.061.09 ± 0.110.81 ± 0.13
150 mg/kg5.93 ± 0.750.55 ± 0.051.33 ± 0.101.25 ± 0.370.74 ± 0.11
300 mg/kg5.08 ± 0.370.54 ± 0.041.22 ± 0.061.37 ± 0.250.86 ± 0.44

Mice were administered with 60, 120, and 240mg/kg doses of HEEF, with 75, 150, and 300mg/kg doses of HEAI for 28 days, and mean body weight and organ weight were recorded before the treatment (day 0) and on days 7, 14, 21, and 28. The control group received 200 µL of distilled water.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.