Hydroethanolic Extracts of Erigeron floribundus and Azadirachta indica Reduced Plasmodium berghei Parasitemia in Balb/c Mice
Table 4
Body and organ weights of rats subjected to subacute toxicity assessment of the hydroethanolic extracts of E. floribundus and A. indica.
Groups
Body weight (g) ± SD
Day 0
Day 7
Day 14
Day 21
Day 28
(A) Rats treated with HEEF
Control
123.3±9.1
127.8±8.8
131.8±9.2
136.8±8.8
143.5±9.5
60 mg/kg
123.3 ± 10.3
126.3 ± 9.7
129.8 ± 9.6
131.8 ± 9.9
134.7±10.2
120 mg/kg
123.3 ± 8.8
126.3 ± 9.0
129.7 ± 11.5
130.3 ± 8.2
133.0±7.7
240 mg/kg
123.0 ± 13.1
126.4 ± 12.5
130.4 ± 8.6
132.0±10.7
134.2±10.6
Groups
Organ weight (g) ± SD
Liver
Heart
Kidneys
Lungs
Spleen
Control
5.72 ± 0.66
0.62 ± 0.05
1.28 ± 0.13
1.16 ± 0.11
0.78 ± 0.19
60 mg/kg
5.15 ± 0.58
0.60 ± 0.08
1.26 ± 0.13
1.51 ± 0.65
0.80 ± 0.14
120 mg/kg
4.54 ± 1.46
0.54 ± 0.05
1.21 ± 0.09
1.39 ± 0.36
0.70 ± 0.15
240 mg/kg
5.16 ± 0.32
0.52 ± 0.06
1.17 ± 0.04
1.40 ± 0.53
0.79 ± 0.19
Groups
Body weight (g) ± SD
Day 0
Day 7
Day 14
Day 21
Day 28
(B) Rats treated with HEAI
Control
123.3 ± 9.11
127.8 ± 8.8
131.8 ± 9.2
136.8 ± 8.8
143.5 ± 9.5
75 mg/kg
123.2 ± 15.3
127.0 ± 15.0
130.0 ± 14.5
136.6 ± 13.7
139.3± 4.6
150 mg/kg
123.5 ± 10.2
128.0 ± 10.4
131.5 ± 9.4
136.0 ± 9.3
141.0±10.0
300 mg/kg
122.7 ± 5.8
126.5 ± 5.5
130.0 ± 5.8
133.7 ± 6.3
137.2 ± 6.5
Groups
Organ weight (g) ± SD
Liver
Heart
Kidneys
Lungs
Spleen
Control
5.72 ± 0.66
0.62 ± 0.05
1.28 ± 0.13
1.16 ± 0.11
0.78 ± 0.19
75 mg/kg
5.65 ± 0.58
0.56 ± 0.06
1.25 ± 0.06
1.09 ± 0.11
0.81 ± 0.13
150 mg/kg
5.93 ± 0.75
0.55 ± 0.05
1.33 ± 0.10
1.25 ± 0.37
0.74 ± 0.11
300 mg/kg
5.08 ± 0.37
0.54 ± 0.04
1.22 ± 0.06
1.37 ± 0.25
0.86 ± 0.44
Mice were administered with 60, 120, and 240mg/kg doses of HEEF, with 75, 150, and 300mg/kg doses of HEAI for 28 days, and mean body weight and organ weight were recorded before the treatment (day 0) and on days 7, 14, 21, and 28. The control group received 200 µL of distilled water.
