Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3K/Akt/mTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells

Figure 3

In vivo effect of NPC01 in NPC xenograft model. 5–8F cells were subcutaneously injected into the right sides of nude mice for 12 days. Then mice were daily subjected to the intragastric administration of NPC01 at the indicated doses. (a) The tumor masses were photographed at the end of the treatment. (b) The tumor volumes were measured and calculated as described in Materials and Methods. (c) Apoptotic cells were stained using a TUNEL kit and counted as described in Materials and Methods. (d) Groups showed a significant tumor-inhibiting effect. The tumor-inhibiting rate was 87.32%, 77.55%, and 56.16%, respectively. Symbol indicates compared with the saline-injected mice.

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