Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats

Figure 8

Effects of high-fat diet and EA on Sirt1-dependent deacetylation of histone and NF-κB. In the results of acetylation status of H3K9, there was a great increased acetylation level in Obesity group, P<0.001 versus Normal group. It was observed that EA and Resveratrol promoted deacetylation effect, ###P<0.001 versus Obesity group. Moreover, the acetylation status of H3K9 in Resveratrol group was lower than EA ($$$P<0.001 versus EA group). When it comes to NF-κB, the acetylation status was not sensitive to EA delivery. Resveratrol downregulated the acetylation status of NF-κB (#P<0.05 versus Obesity group) which was enhanced by high-fat diet (P<0.01 versus Normal group).