Danggui Sini Decoction Protected Islet Endothelial Cell Survival from Hypoxic Damage via PI3K/Akt/eNOS Pathway

<div>Cell survival and proliferation were protected by DSD-CS from hypoxia-induced damage. (a-c) The cell survival capacity was measured by TUNEL assay and CCK8 assay. *P &lt; 0.05 and ***P &lt; 0.001 versus vehicle group (V); #P &lt; 0.05 and ###P &lt; 0.001 versus CoCl2 + vehicle group (V); &amp;P &lt; 0.05 and &amp;&amp;P &lt; 0.01 versus CoCl2 + DSD group. (d-f) The cell proliferation was measured by EdU assay and PCNA expression. *P &lt; 0.05 and ***P &lt; 0.001 versus vehicle group (V); #P &lt; 0.05 and ##P &lt; 0.01 versus CoCl2 + vehicle group (V); &amp;P &lt; 0.05 and &amp;&amp;P &lt; 0.01 versus CoCl2 + DSD group. Scale bars: 200 μm.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Danggui Sini Decoction Protected Islet Endothelial Cell Survival from Hypoxic Damage via PI3K/Akt/eNOS Pathway 