Mechanisms of Antiulcer Effect of an Active Ingredient Group of Modified Xiao Chaihu Decoction
Table 1
Effect of AIG treatment in ethanol-induced gastric ulcers in mice, pylorus ligature-induced, and acetic acid-induced gastric ulcer in rats. Data are presented as mean ± SEM and analyzed by ANOVA followed by a Dunnett’s test.
Gastric ulcer model
Treatments (p.o.)
Dose (g/kg)
Ulcer index (mm)
Inhibition (%)
Ethanol-induced
Saline
–
8
14.37 ± 2.88
–
Ranitidine
0.04
8
11.27 ± 2.49
29.01
AIG
1.50
8
3.11 ± 0.47
80.43
AIG
0.75
8
4.46 ± 0.51
71.93
Pylorus ligature-induced
Saline
–
8
11.33 ± 3.78
–
Ranitidine
0.03
8
3.55 ± 0.63
68.68
AIG
1.0
8
2.76 ± 0.67
75.63
AIG
0.5
8
3.36 ± 0.78
70.33
Acetic acid-induced
Saline
–
8
10.26 ± 1.52
–
Ranitidine
0.03
8
3.89 ± 0.48
64.37
AIG
1.0
8
2.84 ± 0.53
72.49
AIG
0.5
8
3.38 ± 0.64
63.15
, significantly different from saline-treated animals.
