Genotoxicity Evaluation of an Ethanol Extract Mixture of Astragali Radix and Salviae miltiorrhizae Radix
Table 1
Chromosomal aberrations by Myelophil with and without S9 activation.
Condition
Dose (μg/mL)
Chromosome aberrations (N. in 300 cells)
Aberration rate (%)
Break
Exchange
Numerical
Sum
0-24h S9 mix(-)
0
1
0
0
1
0.33
20.68
2
0
0
2
0.67
61.73
1
1
0
2
0.67
185.19
2
0
0
2
0.67
MC (0.04)
9
64
0
73
24.33
6-18h S9 mix(-)
0
1
0
0
1
0.33
20.68
0
1
0
1
0.33
61.73
2
1
0
3
1.00
185.19
2
1
0
3
1.00
MC
14
56
0
70
23.33
6-18h S9 mix(+)
0
1
1
0
2
0.67
61.73
0
2
0
2
0.67
185.19
1
1
0
2
0.67
555.56
2
0
0
2
0.67
CPA (10)
10
62
0
72
24.00
Structural (chromosomal break or exchange) and numerical aberration (polyploidy or endoreduplication) were counted in 300 CHO-K1 cells. MC: mitomycin C; CPA: cyclophosphamide. p < 0.01 vs. negative control.
