Genotoxicity Evaluation of an Ethanol Extract Mixture of Astragali Radix and Salviae miltiorrhizae Radix

Table 2

Bone marrow micronucleus assay results of male mice.

Dose; (mg/kg bw/day)	Body weight (g)		MNPCE/4000 PCEs(Mean ± SD, %)	PCE/(PCE+NCE)
	day 0	day 2
0	34.3 ± 1.4	34.2 ± 4.5	0.19 ± 0.09	0.57 ± 0.01
500	35.1 ± 1.4	35.7 ± 1.3	0.20 ± 0.07	0.56 ± 0.01
1000	35.7 ± 1.2	35.7 ± 1.3	0.20 ± 0.08	0.54 ± 0.05
2000	34.8 ± 0.7	35.7 ± 0.8	0.23 ± 0.06	0.57 ± 0.02
MC (2.0)	35.5 ± 1.2	36.0 ± 1.3	9.59 ± 1.74	0.41 ± 0.05

Micronucleus assay was conducted in ICR mice after oral administration for 2 days, and then the number of MNPCE (micronucleated polychromatic erythrocytes) in 4,000 PCE (polychromatic erythrocyte) was analysed. The proportion of PCE and NCE (normochromatic erythrocytes) in 500 erythrocytes was determined. MC: mitomycin C. p < 0.01 vs. negative control.