Safety Assessment of the Auto Manipulation Device for Acupuncture in Sprague-Dawley Rats: Preclinical Evaluation of the Prototype

Table 1

Baseline vital signs, hemogram, and biochemistry laboratory data in single intervention.

Baseline vital signs	Control group (n=4)	AMDA group (n=8)	P
HR (bpm)	377.8±15.9	355.9±16.8	.056
SBP (mmHg)	89.0±4.5	85.6±6.5	.379
MBP (mmHg)	70.3±4.6	63.1±7.3	.109
DBP (mmHg)	61.0±5.0	52.0±9.5	.110
Vital signs	Control group (n=4)	AMDA group (n=8)	P
HR (bpm)	431.3±43.4	423.4±40.1	.734
SBP (mmHg)	103.5±20.6	101.4±18.5	.932
MBP (mmHg)	80.5±9.7	80.1±12.9	.865
DBP (mmHg)	69±4.8	69.8±10.3	1.000
Hemogram
WBC (1000/uL)	5.25±3.78	5.79±3.32	.610
RBC (million/uL)	5.013±1.513	5.28±1.496	.610
Hb (g/dL)	10.63±3.43	11.19±3.25	.552
Hct (%)	33.65±11.01	35.83±10.34	.396
MCV (fL)	66.7±2.28	67.81±2.68	.497
MCH (pg/Cell)	21.08±0.67	21.18±0.64	.495
MCHC (gHb/dL)	31.6±0.22	31.23±0.73	.200
Plt (1000/uL)	436.5±494.4	470.3±420.6	.552
Seg (%)	21.98±12.26	15.13±6.04	.308
Lym (%)	74.3±14.29	82.56±6.1	.396
Mono (%)	3.45±2.34	1.75±0.99	.234
Eosin (%)	0.1±0.2	0.38±0.43	.096
Baso (%)	0.18±0.21	0.19±0.15	.930
Biochemistry laboratory data
BUN (mg/dL)	11.95±3.72	11.24±2.33	.609
Cr (mg/dL)	0.27±0.062	0.244±0.041	.670
Na (mEq/L)	146±0.8	146.1±1.8	1.000
K (mEq/L)	5.93±0.57	6.59±0.29	.061
AST (U/L)	112.3±5.3	111.3±7.8	.932
ALT (U/L)	44.5±4.2	49.6±7.5	.147

HR, heart rate; SBP, systolic blood pressure; MBP, mean blood pressure; DBP, diastolic blood pressure. WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; Plt, platelet; Seg, segment; Lym, lymphocyte; Mono, monocyte; Eosin, eosinophil; Baso, basophil. BUN, blood urea nitrogen; Cr, Creatinine; Na, sodium; K, potassium; AST, aspartate aminotransferase; ALT, alanine aminotransferase.
Mean ± standard deviation was presented for vital signs (HR, SBP, MBP, and DBP), hemogram (complete blood count and differential count), and biochemistry laboratory data (BUN/Cr, Na/K, and AST/ALT). No significant difference between the 2 groups was found at baseline and once intervention study.