Safety Assessment of the Auto Manipulation Device for Acupuncture in Sprague-Dawley Rats: Preclinical Evaluation of the Prototype
Table 2
Vital signs, hemogram, and biochemistry laboratory data in repeated sessions study.
Control group (n=3)
AMDA group (n=12)
P
Rat body weight gain (%)
12.85±2.25
12.69±2.65
.942
Vital signs
HR (bpm)
411.3±17.4
382.7±29.7
.149
SBP (mmHg)
84.7±11.2
87.1±9.8
.771
MBP (mmHg)
68.3±13
67.3±10.6
1.000
DBP (mmHg)
59.3±14.2
57.6±11.8
.828
Hemogram
WBC (1000/uL)
7.4±2.96
8.43±4.09
.613
RBC (million/uL)
6.357±1.384
6.801±0.698
.773
Hb (g/dL)
13.47±2.8
14.21±1.3
.772
Hct (%)
41.83±8.82
44.48±3.89
.773
MCV (fL)
65.87±0.81
65.58±3.11
.563
MCH (pg/Cell)
21.2±0.26
20.93±0.89
.347
MCHC (gHb/dL)
32.23±0.21
31.94±0.36
.128
Plt (1000/uL)
516.7±373.2
523.7±322.2
.885
Seg (%)
16.33±2.25
16±7.41
.248
Lym (%)
81.5±2.43
81.45±7.45
.278
Mono (%)
1.4±0.1
1.53±0.93
.884
Eosin (%)
0.5±0.2
0.76±0.6
.563
Baso (%)
0.27±0.06
0.26±0.12
.939
Biochemistry laboratory data
BUN (mg/dL)
15.2±3.87
14.3±3.43
.773
Cr (mg/dL)
0.213±0.015
0.23±0.045
.716
Na (mEq/L)
145.3±1.5
146.8±2.2
.210
K (mEq/L)
6.57±0.12
6.93±0.61
.346
AST (U/L)
121.7±16.3
125.8±23.7
.885
ALT (U/L)
50.7±2.3
54.1±8.1
.469
Mean ± standard deviation was presented for the percentage of rat body weight gain, vital signs (HR, SBP, MBP, and DBP), hemogram (complete blood count and differential count), and biochemistry laboratory data (BUN/Cr, Na/K, and AST/ALT). No significant difference between the 2 groups was found at chronic AMDA study.
