Effects of Methanol Fraction from Leaves of Schinus terebinthifolius Raddi on Nociception and Spinal-Cord Oxidative Biomarkers in Rats with Neuropathic Pain
Table 2
Effect of methanol fraction (MeF) from Schinus terebinthifolius (20 mg/kg/day) on locomotor activity and anxiety-like behaviors in naive rats.
Parameters
Elevated plus-maze test (EPM)
values
Saline
MeF
Mean
±SE
Mean
±SE
% Time in open arms (s)
13.29
3.13
17.54
4.76
0.472
% Time in closed arms (s)
86.71
3.13
82.46
4.76
0.472
% Entries in open arms
21.49
3.63
19.73
4.12
0.753
% Entries in closed arms
78.51
3.63
80.27
4.12
0.753
Number of rearings in open arms
0.00
0.00
0.00
0.00
-
Number of head dips
7.42
2.36
7.42
1.82
1.0
Risk assessment (s)
16.53
4.27
19.34
3.41
0.612
Parameters
Open field test (OF)
values
Saline
MeF
Median
25%
75%
Median
25%
75%
Total crossings
52.0
38.0
64.0
56.0
40.0
72.0
0.532
Peripheral crossings
45.0
35.0
50.0
44.0
36.0
50.0
0.818
Central crossings
2.0
1.0
5.0
4.0
0.0
8.0
0.447
Time in central area (s)
3.6
0.7
7.2
9.1
1.7
24.6
0.189
Latency to 1° crossing (s)
7.1
3.0
11.1
6.1
5.0
10.0
0.948
Latency to enter central area (s)
110.0
47.1
154.1
68.1
62.1
158.0
0.844
Rearings
14.0
11.0
23.0
23.0
12.0
29.0
0.292
Freezing (s)
0.0
0.0
10.8
0.0
0.0
0.0
0.108
Grooming (s)
3.9
0.0
8.1
1.0
0.0
15.0
0.946
Results are expressed as means ± SE for EPM; median and percentiles for OF, rats. No significant differences were found between the groups (Student’s -test, for EPM; Mann–Whitney test, for OF; ).
