Investigation into the Individualized Treatment of Traditional Chinese Medicine through a Series of N-of-1 Trials
Table 2
The mean value of patient self-reported symptom scores (individualized decoction versus control decoction) of each N-of-1 trial.
Number of case
Control decoction
Individualized decoction
Mean difference (95% CI)
-value
Preference to the two decoctions
Cycle 1
cycle 2
cycle 3
Cycle 1
cycle 2
cycle 3
Case
1.46
1.41
1.11
1.44
1.49
1.11
−0.02 (−0.16, 0.11)
0.54
No
Case
3.07
-
2.85
3.00
-
3.11
No
Case
3.33
3.49
3.19
2.80
2.84
3.37
0.34 (−0.78, 1.45)
0.32
Individualized decoction
Case
2.06
1.68
1.56
1.91
1.62
1.67
0.03 (−0.29, 0.36)
0.71
No
Case
-
-
2.27
-
-
2.23
Individualized decoction
Case
1.67
1.63
1.83
1.53
1.71
1.83
0.02 (−0.25, 0.29)
0.78
No
Case
3.13
2.63
2.70
2.66
2.34
2.23
0.41 (0.15, 0.67)
0.02
No
Case
3.40
2.52
2.38
2.83
2.40
-
No
Case
1.89
2.06
1.88
1.79
1.91
2.00
0.04 (−0.32, 0.41)
0.66
No
Case
2.20
2.10
2.07
2.07
1.80
1.83
0.22 (0.02, 0.43)
0.04
No
Case
2.68
2.28
2.12
2.54
2.20
2.01
0.11 (0.03, 0.19)
0.03
No
Case
3.46
2.89
2.79
3.17
2.74
2.49
0.25 (0.03, 0.47)
0.04
No
Case
2.48
2.14
1.76
2.10
1.81
1.39
0.36 (0.30, 0.42)
0.001
No
Case
1.69
-
1.71
1.36
-
1.36
No
were not included in the statistical analysis due to an acute exacerbation during the cycle. individual statistic analysis due to incomplete data. as “responder” according to the clinical criteria.
