Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study
Table 4
Time course of urinary protein excretion (g per 24 h) in individual patients with RMN from entry into the study (baseline) to end of study (month 12).
Patient no.
Primary IST
Indication
Baseline
Month 3
Month 6
Month 12
Baseline to month 12a
Urinary protein excretion
Serum albumin
urinary protein excretion
Serum albumin
urinary protein excretion
Serum albumin
urinary protein excretion
Serum albumin
urinary protein excretion
Serum albumin
1
cCTX/GC
Resistant
4.40
27.90
6.31
20.20
6.18
20.20
3.59
35.20
-0.81
7.30
2
CsA/GC
Intolerant
5.60
22.50
2.80
26.70
5.70
18.00
3.75
18.80
-1.85
-3.70
3
CsA/GC
Relapse
4.47
24.20
2.82
37.90
1.60
40.00
1.13
41.00
-3.34
16.80
4
cCTX/GC
Resistant
4.00
25.30
2.65
37.50
0.56
46.10
1.28
47.00
-2.72
21.70
5
cCTX/GC
Resistant
7.28
22.10
5.07
24.66
2.87
32.89
1.33
45.00
-5.95
22.90
6
TAC
Intolerant
4.80
23.70
3.08
29.30
1.16
44.60
1.60
44.32
-3.20
20.62
7
TAC
Intolerant
5.72
25.92
3.18
34.54
3.78
34.97
2.78
40.00
-2.94
14.08
8
CsA/GC
Relapse
10.00
19.00
6.92
25.40
3.34
28.10
2.11
38.60
-7.89
19.60
9
cCTX/GC
Resistant
6.17
24.00
4.58
30.40
1.63
46.60
0.17
47.36
-6.00
23.36
10
CsA/GC
Relapse
3.10
27.10
1.45
43.00
0.23
49.00
0.21
49.00
-2.89
21.90
11
CsA/GC
Relapse
5.10
24.50
2.00
44.50
1.80
41.40
1.13
45.00
-3.97
20.50
12
cCTX/GC
Resistant
6.08
26.30
3.44
30.60
3.25
39.40
1.78
42.00
-4.30
15.70
13
CsA/GC
Resistant
5.08
24.20
2.47
41.80
1.58
39.70
2.45
39.70
-2.63
15.50
14
cCTX/GC
Relapse
4.20
23.70
6.80
14.80
6.20
14.50
3.30
21.80
-0.90
-1.90
15
CsA/GC
Resistant
13.00
15.80
5.53
15.40
5.20
18.00
3.32
29.63
-9.68
13.83
Mean
/
/
5.93
23.88
3.94
30.45
3.01
34.23
1.99
38.96
-3.94
15.21
SD
/
/
2.54
3.28
1.78
9.47
2.02
11.69
1.17
9.08
2.48
8.48
Median
/
/
5.10
24.20
3.17
30.40
2.86
39.40
1.78
41.00
-3.20
16.80
Abbreviations. RMN: refectory membranous nephropathy; IST: immunosuppressive therapy; cCTX/GC: cyclical cyclophosphamide and steroids; TAC: tacrolimus; CsA/GC: cyclosporin and steroids. t-test P<0.001 for 12-month change.
