Therapeutic Effects of Kangzhi Syrup in a Guinea Pig Model of Ovalbumin-Induced Cough Variant Asthma
Table 1
Grade of fibrosis
Manifestations
0
Alveolar septa: no fibrotic burden at the most flimsy small fibers in some alveolar walls Lung structure: normal lung
1
Alveolar septa: isolated gentle fibrotic changes (septum ≤ 3 × thicker than normal) Lung structure: alveoli partly enlarged and rarefied, but no fibrotic masses present
2
Alveolar septa: clearly fibrotic changes (septum > 3 × thicker than normal) with knot-like formation but not connected to each other Lung structure: alveoli partly enlarged and rarefied, but no fibrotic masses
3
Alveolar septa: contiguous fibrotic walls (septum > 3 × thicker than normal) predominantly in whole microscopic field Lung structure: alveoli partly enlarged and rarefied, but no fibrotic masses
4
Alveolar septa: variable Lung structure: single fibrotic masses (≤10% of microscopic field)
5
Alveolar septa: variable Lung structure: confluent fibrotic masses (>10% and ≤50% of microscopic field). Lung structure severely damaged but still preserved
6
Alveolar septa: variable, mostly not existent Lung structure: large contiguous fibrotic masses (>50% of microscopic field). Lung architecture mostly not preserved
7
Alveolar septa: nonexistent Lung structure: alveoli nearly obliterated with fibrous masses but still up to five air bubbles
8
Alveolar septa: nonexistent Lung structure: microscopic field with complete obliteration with fibrotic masses