<i>Apocynum venetum</i> Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress

<div>Effect of AVLE on neuronal apoptosis of hippocampus and cortex of CUMS rats. (a, b) TUNEL staining in the hippocampus DG region and cortex of CUMS rats. (c, d) Quantification of TUNEL-positive cells in the hippocampus and cortex. Scale bars: 50 <i>μ</i>m. 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transform="matrix(.013,0,0,-0.013,52.233,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,58.473,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg> compared with the CUMS group. CON: control; CUMS: chronic unpredictable mild stress; AVLE:<i> Apocynum venetum</i> leaf extract (120 mg/kg); TUNEL: terminal deoxyribonucleotidyl transferase- (TDT-) mediated dUTP-digoxigenin nick end labeling.</div>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: <i>Apocynum venetum</i> Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress 

Figure 3 | Apocynum venetum Leaf Extract Exerts Antidepressant-Like Effects and Inhibits Hippocampal and Cortical Apoptosis of Rats Exposed to Chronic Unpredictable Mild Stress 