Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model

Figure 4

NK cell activities in intact or CPA-induced immunosuppressive mice. Significant decreases of splenic and peritoneal NK cell activities were observed in CPA control mice as compared with intact vehicle control mice, respectively. However, significant increases of splenic and peritoneal NK cell activities were detected in all test substance-administered mice including β-glucan 250 mg/kg oral administered mice as compared with CPA control mice, respectively. All three different dosages of MHFe-treated mice, especially, showed obvious dose-dependent inhibitory effects on CPA-induced decreases of NK cell activities as similar as equal dosages of β-glucan, in this experiment; values are expressed mean ± SD of eight mice; CPA: cyclophosphamide; MHFe: two-sweetener-excluded Kuseonwangdogo-based mixed herbal formula aqueous extracts; NK: natural killer; as compared with intact control mice by LSD test; and as compared with CPA control mice by LSD test; as compared with intact control mice by MW test; as compared with CPA control mice by MW test.