Drug-Repositioning Approach for the Discovery of Anti-Influenza Virus Activity of Japanese Herbal (Kampo) Medicines In Vitro: Potent High Activity of Daio-Kanzo-To
Table 2
Antiviral effect of Daio-kanzo-to and its constituents on various influenza viruses.
IC50 (μg/mL
Strain
Subtype
Daio-kanzo-to (TJ-84)
Rhubarb
JP Glycyrrhiza
Sennoside A
Sennoside B
Oseltamivir
Amantadine
A/WSN/33
H1N1
10.5±5.5
10.4±6.2
>100
>173
>173
2.1±0.4
80.9±32.6
A/Puerto Rico/8/34
H1N1
8.0±0.2
21.6±1.5
>100
>173
>173
2.0±0.2
>188
A/Aichi/2/68
H3N2
15.9±7.3
20.9±1.2
>100
>173
>173
0.4±0.1
0.1±0.0
A/California/7/2009
H1N1
16.7±3.6
20.0±4.4
>100
>173
>173
0.4±0.0
>188
A/Virginia/ATCC2/2009
H1N1
20.6±4.2
19.1±2.1
>100
>173
>173
>41.0
>188
% inhibitory concentration. Japanese Pharmacopoeia. available Rhubarb crude drug (Zaiseidoyakuhin Co., Ltd.) available Glycyrrhiza crude drug (Kracie Holdings, Ltd.).
