<i>Piper retrofractum</i> Vahl. Extract, as a PPAR<i>δ</i> and AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs Inhibition in Human Dermal Fibroblasts and Hairless Mice

<div>The effects of PRE on collagen gene transcription and its mechanism<i> in vitro</i>. (a) The expression of collagen genes was investigated by RT-PCR. (b) The expression of TGF-<i>β</i>/Smad signaling was measured by Western blot. Equal mRNA and protein loading were identified by GAPDH and <i>α</i>-tubulin, respectively. 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Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: <i>Piper retrofractum</i> Vahl. Extract, as a PPAR<i>δ</i> and AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs Inhibition in Human Dermal Fibroblasts and Hairless Mice 

Figure 3 | Piper retrofractum Vahl. Extract, as a PPARδ and AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs Inhibition in Human Dermal Fibroblasts and Hairless Mice 