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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 6172954, 11 pages
https://doi.org/10.1155/2018/6172954
Research Article

Piper retrofractum Vahl. Extract, as a PPARδ and AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs Inhibition in Human Dermal Fibroblasts and Hairless Mice

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea

Correspondence should be addressed to Jae-Kwan Hwang; rk.ca.iesnoy@gnawhkj

Received 8 November 2017; Revised 31 December 2017; Accepted 17 January 2018; Published 12 February 2018

Academic Editor: Darren R. Williams

Copyright © 2018 Jungon Yun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Ramos-e-Silva, L. R. Celem, S. Ramos-e-Silva, and A. P. Fucci-da-Costa, “Anti-aging cosmetics: Facts and controversies,” Clinics in Dermatology, vol. 31, no. 6, pp. 750–758, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Sjerobabski-Masnec and M. Šitum, “Skin aging,” Acta clinica Croatica, vol. 49, no. 4, pp. 515–518, 2010. View at Google Scholar · View at Scopus
  3. M. Kim, Y. G. Park, H.-J. Lee, S. J. Lim, and C. W. Nho, “Youngiasides A and C isolated from Youngia denticulatum inhibit UVB-induced MMP expression and promote Type I procollagen production via repression of MAPK/AP-1/NF-κB and activation of AMPK/Nrf2 in HaCaT cells and human dermal fibroblasts,” Journal of Agricultural and Food Chemistry, vol. 63, no. 22, pp. 5428–5438, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Jugé, J. Breugnot, C. Da Silva, S. Bordes, B. Closs, and A. Aouacheria, “Quantification and characterization of UVB-induced mitochondrial fragmentation in normal primary human keratinocytes,” Scientific Reports, vol. 6, Article ID 35065, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. P. K. Kamat, A. Kalani, P. Kyles, S. C. Tyagi, and N. Tyagi, “Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease,” Cell Biochemistry and Biophysics, vol. 70, no. 2, pp. 707–719, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. M. L. Paz, D. H. G. Maglio, F. S. Weill, J. Bustamante, and J. Leoni, “Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes,” Photodermatology, Photoimmunology & Photomedicine, vol. 24, no. 3, pp. 115–122, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. B. Vega, T. C. Leone, and D. P. Kelly, “Transcriptional control of mitochondrial biogenesis and maturation,” Cardiac Energy Metabolism in Health and Disease, pp. 89–102, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. S. A. Ham, T. Yoo, J. S. Hwang et al., “Peroxisome proliferator-activated receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to ultraviolet B radiation,” Journal of Dermatological Science, vol. 76, no. 1, pp. 44–50, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. S. A. Ham, H. J. Kim, H. J. Kim et al., “PPARδ promotes wound healing by up-regulating TGF-β1-dependent or -independent expression of extracellular matrix proteins,” Journal of Cellular and Molecular Medicine, vol. 14, no. 6 B, pp. 1747–1759, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. B. Hock and A. Kralli, “Transcriptional control of mitochondrial biogenesis and function,” Annual Review of Physiology, vol. 71, pp. 177–203, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. G. López-Lluch, P. M. Irusta, P. Navas, and R. de Cabo, “Mitochondrial biogenesis and healthy aging,” Experimental Gerontology, vol. 43, no. 9, pp. 813–819, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Palikaras and N. Tavernarakis, “Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis,” Experimental Gerontology, vol. 56, pp. 182–188, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Sárdy, “Role of matrix metalloproteinases in skin ageing,” Connective Tissue Research, vol. 50, no. 2, pp. 132–138, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Kammeyer and R. M. Luiten, “Oxidation events and skin aging,” Ageing Research Reviews, vol. 21, pp. 16–29, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. S. A. Ham, E. S. Kang, H. Lee et al., “PPARδ inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling,” Journal of Investigative Dermatology, vol. 133, no. 11, pp. 2593–2600, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. D. J. Shin, J.-E. Kim, T.-G. Lim et al., “20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway,” Journal of Cellular Biochemistry, vol. 115, no. 10, pp. 1702–1711, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. H. S. Lee, “Pesticidal constituents derived from Piperaceae fruits,” Journal of Applied Biological Chemistry, vol. 48, no. 2, pp. 65–74, 2005. View at Google Scholar
  18. K. J. Kim, M.-S. Lee, K. Jo, and J.-K. Hwang, “Piperidine alkaloids from Piper retrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase,” Biochemical and Biophysical Research Communications, vol. 411, no. 1, pp. 219–225, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. T. He, T. Quan, Y. Shao, J. J. Voorhees, and G. J. Fisher, “Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts,” AGE, vol. 36, article 9623, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Wang, J. Liu, Y. Li et al., “Peroxisome proliferator-activated receptor δ is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart,” Circulation Research, vol. 106, no. 5, pp. 911–919, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Jäger, C. Handschin, J. S. Pierre, and B. M. Spiegelman, “AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 104, no. 29, pp. 12017–12022, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. V. A. Narkar, M. Downes, R. T. Yu et al., “AMPK and PPARδ agonists are exercise mimetics,” Cell, vol. 134, no. 3, pp. 405–415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. M. Mihaylova and R. J. Shaw, “The AMPK signalling pathway coordinates cell growth, autophagy and metabolism,” Nature Cell Biology, vol. 13, no. 9, pp. 1016–1023, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Wu, W. Tian, Z. Hu et al., “ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy,” EMBO Reports, vol. 15, no. 5, pp. 566–575, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Pandel, B. Poljšak, A. Godic, and R. Dahmane, “Skin photoaging and the role of antioxidants in its prevention,” ISRN Dermatology, vol. 2013, Article ID 930164, 11 pages, 2013. View at Publisher · View at Google Scholar
  26. B. Baek, S. H. Lee, K. Kim, H.-W. Lim, and C.-J. Lim, “Ellagic acid plays a protective role against UV-B-induced oxidative stress by up-regulating antioxidant components in human dermal fibroblasts,” Korean Journal of Physiology & Pharmacology, vol. 20, no. 3, pp. 269–277, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Oh, H.-W. Lim, Y.-H. Huang et al., “Attenuating properties of Agastache rugosa leaf extract against ultraviolet-B-induced photoaging via up-regulating glutathione and superoxide dismutase in a human keratinocyte cell line,” Journal of Photochemistry and Photobiology B: Biology, vol. 163, pp. 170–176, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. Z. Sun, S. Y. Park, E. Hwang et al., “Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways,” Phytomedicine, vol. 23, no. 12, pp. 1273–1284, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Wasito, H. Ekowati, and F. F. Hayati, “In vitro antioxidant activity of Zingiber officinale, Piper retrofractum, and their combinations,” Indonesian Journal of Cancer Chemoprevention, vol. 2, no. 3, pp. 295–298, 2011. View at Google Scholar
  30. A. Chanwitheesuk, A. Teerawutgulrag, and N. Rakariyatham, “Screening of antioxidant activity and antioxidant compounds of some edible plants of Thailand,” Food Chemistry, vol. 92, no. 3, pp. 491–497, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. A. B. Tukun, N. Shaheen, C. P. Banu, M. Mohiduzzaman, S. Islam, and M. Begum, “Antioxidant capacity and total phenolic contents in hydrophilic extracts of selected Bangladeshi medicinal plants,” Asian Pacific Journal of Tropical Medicine, vol. 7, no. 1, pp. S568–S573, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Meng, Z. Pei, A. Zhang et al., “AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway,” Archives of Biochemistry and Biophysics, vol. 511, no. 1-2, pp. 1–7, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. J.-E. Kim, Y.-W. Kim, K. L. In, J.-Y. Kim, J. K. Young, and S.-Y. Park, “AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide- 1-β-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression,” Journal of Pharmacological Sciences, vol. 106, no. 3, pp. 394–403, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. R. Jung, E. K. Lee, D. H. Kim et al., “Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza,” Journal of Natural Products, vol. 78, no. 8, pp. 2110–2115, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Ryser, M. Schuppli, B. Gauthier et al., “UVB-induced skin inflammation and cutaneous tissue injury is dependent on the MHC class I-like protein, CD1d,” Journal of Investigative Dermatology, vol. 134, no. 1, pp. 192–202, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Degueurce, I. D'Errico, C. Pich et al., “Identification of a novel PPARβ/δ/miR‐21‐3p axis in UV‐induced skin inflammation,” EMBO Molecular Medicine, vol. 8, no. 8, pp. 919–936, 2016. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Romanowska, L. Reilly, C. N. A. Palmer, M. C. U. Gustafsson, and J. Foerster, “Activation of PPARβ/δ causes a psoriasis-like skin disease in vivo,” PLoS ONE, vol. 5, no. 3, Article ID e9701, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. C. I. Schnegg, M. Kooshki, F.-C. Hsu, G. Sui, and M. E. Robbins, “PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway,” Free Radical Biology & Medicine, vol. 52, no. 9, pp. 1734–1743, 2012. View at Publisher · View at Google Scholar · View at Scopus