Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 3

Research Article

A Systematic Review of Herbal Medicine for Chemotherapy Induced Peripheral Neuropathy

Table 3

Composition of the herbal formulas for CIPN in this review.

First author, year Composition (daily dosage)

Nishioka, 2011;   
Kaku, 2012;
Abe, 2013;
Koto, 2013;   
Oki, 2015
Goshajinkigan granule: Rehmanniae Radix (10.7%), Achyranthis Radix (6.4%), Corni fructus (6.4%), Moutan Cortex (6.4%), Alismatis Rhizome (6.4%), Dioscoreae Rhizome (6.4%), Plantaginis Semen (6.4%), Poria (6.4%), processed Aconiti Tuber (2.1%), Cinnamomi Cortex (2.1%)
(a mixture of aqueous extracts in fixed proportions)

Zhu, 2007;
Liu, 2013
Guilong tongluo decoction: Ramulus Cinnamomi (9), Earthworm (12), Radix Astragali (30), Safflower (10), Radix Angelicae sinensis (12), Ligusticum (12), Spatholobus (30), Radix Paeoniae alba (30), Rhizoma Curcumae (9), licorice (6)

Sun, 2008Yiqi Huoxue decoction: Astragali Radix (30), Angelicae Gigantis Radix (15), Spatholobi Caulis (15), Persicae Semen (10), Paeoniae Radix Rubra (10), Carthami Flos (10), Ligustici Rhizoma (10), Pheretimae Corpus (10), Curcumae Longae Rhizoma (10)
 Addition for numbness: Trachelospermi caulis (15), Chaenomelis Fructus (10)
 Addition for numbness of upper limb: Mori Ramulus (15), Osterici Radix (15)
 Addition for numbness of lower limb: Angelicae Pubescentis Radix (15), Achyranthis Radix (15)
He, 2010Yiqi wenjing tonglou decoction: Astragali Radix (30), Cinnamomi Ramulus (12), Angelicae Gigantis Radix (12), Radix Paeoniae (12), Spatholobi Caulis (10), Pheretimae Corpus (10), Ligustici Rhizoma, Poria (10), Zingiberis Rhizoma Recens (6)
Chen, 2012Huoxue tongluo formula: Zanthoxyli Pericarpium (10), Lycopodii Herba (30), Phryma leptostachya L. var. asiatica (30), Artemisiae Argyi Folium (20), Carthami Flos (10), Paeoniae Radix Rubra (10), Zingiberis Rhizoma Siccus (10), Angelicae Gigantis Radix (20), Pheretimae Corpus (10), Cinnamomi Ramulus (10), Lonicerae Flos (10), Olibanum (20), Myrrha (20)
Luo, 2012Astragali Radix 40 ml (equivalent capacity of 80 g)
Pan, 2012(1) Chaihu jia longgu muli decoction: Pseudostellariae Radix (15), Pinelliae Rhizoma (10), Glycyrrhizae Radix (10), Scutellariae Radix (15), Bupleuri Radix (10), Fossilia Ossis Mastodi (30), Ostreae Concha (30), Oldenlandiae Diffusae Herba (20), Scutellaria Herba (20), Fritillariae Thunbergii Bulbus (20)
(2) Yiqi huayu formula: Astragali Radix (30), Angelicae Gigantis Radix (15), Paeoniae Radix Rubra (15), Pheretimae Corpus (15), Ligustici Rhizoma (10), Carthami Flos (15)
Li, 2013(1) Buyang huanwu decoction: Astragali Radix (15), Angelicae Gigantis Radix (15), Spatholobi Caulis (15), Persicae Semen (15), Paeoniae Radix Rubra (10), Carthami Flos (10), Ligustici Rhizoma (10), Pheretimae Corpus (10)
(2) Herbal formula for hand and foot baths: Taraxaci Herba (30), Semiaquilegia adoxoides (20), Chrysanthemi Indici Flos (20), Forsythiae Fructus (20), Scrophulariae Radix (20), Cicadae Periostracum (15), Sophorae Radix (20), Rehmanniae Radix (15), Cnidii Fructus (20), Phellodendri Cortex (15), Coptidis Rhizoma (6), Atractylodis Rhizoma (15), Kochiae Fructus (20)
Guo, 2015Astragali Radix (40), Geranium Herba (40), Cinnamomi Ramulus (40), Artemisiae Argyi Folium (40), Zedoariae Rhizoma (40), Carthami Flos (40), Ligustici Rhizoma (40), Cyathulae Radix (40), Achyranthis Radix (40), Paeoniae Radix Rubra (40)
Jiang, 2015Siteng yixian formula: Piperis Futokandsurae Caulis (30), Trachelospermi caulis (30), Uncariae Ramulus et Uncus (30), Spatholobi Caulis (30)
Cai, 2016Wenjing Huoxue formula: Cinnamomi Ramulus (30), Lycopodii Herba (30), Angelicae Gigantis Radix (30), Blumeae Herba (30), Menthae Herba (15), Biotae Cacumen (30), Liquidambaris Resina (30), Ligustici Rhizoma (10)
Jia, 2016Shaoyao gouteng muer decoction: Paeoniae Radix Alba (30), Uncariae Ramulus et Uncus (30), Glycyrrhizae Radix (9), Pruni Humilis Semen (6), Lactucae Semen (10), Auriculariae Polyporus (15), Gastrodiae Rhizoma (6), Scorpio (6), Bombycis Corpus cum Batryticatus (9)
Xu, 2016Tanshinone IIA
Jia, 2009Wenloutong formula: Carthami Flos, Aconiti Tuber, etc. (dosage not available)
Han, 2011Wenjing huoxue tonglou formula: Aconiti Tuber Praepareta (40), Cinnamomi Ramulus (40), Ligustici Rhizoma (40), Epimedi Herba (40), Phrymae Herba (40)
Zhang, 2011Baweiyangmai decoction: Astragali Radix (60), Angelicae Gigantis Radix (25), Spatholobi Caulis (20), Cinnamomi Ramulus (15), Pheretimae Corpus (10), Visci Herba (10), Achyranthis Radix (10), Glycyrrhizae Radix (10)
Chen, 2012(1) Modified zhixiao xuanbi decoction: Astragali Radix (60), Rehmanniae Radix (30), Angelicae Gigantis Radix (10), Ligustici Rhizoma (25), Paeoniae Radix (15), Cinnamomi Ramulus (6), Hirudo (6), Carthami Flos (15), Pheretimae Corpus (15), Achyranthis Radix (20), Glycyrrhizae Radix (3), Zingiberis Rhizoma Recens (3)
(2) Fumigation of modified zhixiao xuanbi formula: Astragali Radix (60), Rehmanniae Radix (30), Angelicae Gigantis Radix (10), Ligustici Rhizoma (25), Paeoniae Radix (15), Cinnamomi Ramulus (6), Hirudo (6), Carthami Flos (15), Pheretimae Corpus (15), Achyranthis Radix (20), Glycyrrhizae Radix (3), Zingiberis Rhizoma Recens (3), Sinapis Semen (20), Zingiberis Rhizoma Siccus (20), Zanthoxyli Pericarpium (20)
Zhou, 2013Angelicae Gigantis Radix (30), Mori Folium (20), Spatholobi Caulis (20), Carthami Flos (10), Lycopodii Herba (10), Achyranthis Radix (15), Lycii Fructus (20), Perilla Folium (20), Pini Lignum (20), Homalomena occulta (15), Clematidis Radix (15), Angelicae Pubescentis Radix (15), Cynanchi Paniculati Radix (15), Astragali Radix (20), Acanthopanacis Cortex (15), Photiniae Folium (15)
Wei, 2014Wenyang tongbi formula: Angelicae Pubescentis Radix (10), Taxilli Ramulus (10), Gentianae Macrophyllae Radix (10), Angelicae Gigantis Radix (10), Paeoniae Radix Rubra (10), Asari Herba Cum Radix (3), Cinnamomi Cortex Spissus (6), Hirudo (3), Bombycis Corpus cum Batryticatus (10), Scorpio (3)
Lou, 2014Wenjing tongluo formula: Geranium Herba, Aconiti Tuber, Cinnamomi Ramulus, Carthami Flos (the proportions are 4 : 2 : 3 : 2)
Shen, 2015Modified huangqi guizhi wuwu formula: Astragali Radix (50), Paeoniae Radix Alba (15), Cinnamomi Ramulus (12), Zingiberis Rhizoma Siccus (10), Zizyphi Fructus (10), Angelicae Gigantis Radix (12), Carthami Flos (10), Spatholobi Caulis (30), Clematidis Radix (10)
Ke, 2016Sappan Lignum (30), Cinnamomi Ramulus (12), Lycopodii Herba (30), Salviae Miltiorrhizae Radix (30), Angelicae Pubescentis Radix (30), Osterici Radix (30)

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