<i>Smilax aristolochiifolia</i> Root Extract and Its Compounds Chlorogenic Acid and Astilbin Inhibit the Activity of <i>α</i>-Amylase and <i>α</i>-Glucosidase Enzymes

<div>Molecular docking for chlorogenic acid with <svg height="6.1673pt" id="M103" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 7.51131 6.1673" width="7.51131pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M545 106L524 126C493 85 467 65 455 65C438 65 427 113 405 238C448 295 498 362 543 439L533 448L478 435C453 386 423 331 398 295H395C370 404 347 448 282 448C169 448 23 309 23 153C23 54 65 -12 128 -12C203 -12 283 70 339 155H341C360 29 380 -12 411 -12C444 -12 491 11 545 106ZM333 204C265 95 210 54 169 54C137 54 113 96 113 171C113 302 191 405 252 405C301 405 318 306 333 204Z" id="g113-223"></path></g></svg>-amylase (a). Binding uncompetitive mode (b) and two-dimensional interaction diagram (c). Green and red dashed lines show hydrogen bonds and unfavorable donor-donor interactions, respectively. Residues involved in hydrogen bonds (green circles) are shown.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: <i>Smilax aristolochiifolia</i> Root Extract and Its Compounds Chlorogenic Acid and Astilbin Inhibit the Activity of <i>α</i>-Amylase and <i>α</i>-Glucosidase Enzymes 

Figure 8 | Smilax aristolochiifolia Root Extract and Its Compounds Chlorogenic Acid and Astilbin Inhibit the Activity of α-Amylase and α-Glucosidase Enzymes 