Randomized, Double-Blind, Placebo-Controlled Study of Modified Erzhi Granules in the Treatment of Menopause-Related Vulvovaginal Atrophy

Table 4

Vaginal maturation index.

	groups	baseline	4 weeks	8 weeks	12 weeks	4 weeks after drug withdrawal	p1	p2	p3	p4
percentage of superficial cells	treatment group	0.67±1.18	2.39±0.79	4.28±1.88	5.49±1.64	4.59±1.68	<0.001	<0.001	<0.001	<0.001
	placebo group	1.06±1.24	2.42±0.96	0.86±0.96	0.86±0.96	0.86±1.25	0.410	0.050	0.110	0.040
	p	0.079	<0.001	<0.001	<0.001	<0.001
percentage of basal cells	treatment group	55.23±10.32	44.56±10.74	37.31±8.54	33.85±7.91	41.26±8.48	<0.001	<0.001	<0.001	<0.001
	placebo group	53.53±9.95	53.22±9.79	54.58±9.14	55.17±9.09	57.53±8.78	0.880	0.450	0.180	0.010
	p	0.494	0.001	<0.001	<0.001	<0.001