Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats

Figure 2

MRM chromatograms of eleven analytes. rhein (1), emodin (2), stilbene glycoside (3), glycyrrhizic acid (4), liquiritin (5), liquiritigenin (6), isoliquiritigenin (7), ononin (8), verbascoside (9), gallic acid (10), schisandrin (11), and IS (12). (a) Blank plasma; (b) blank plasma spiked with the analytes and IS; (c) plasma sample after oral administration of TMYX extract.

(a)

(b)

(c)