Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 3

Research Article

Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats

Table 3

Precision and accuracy of 11 analytes in rat plasma (n=6).

compoundsSpiked Concentration (ng/mL)Intra-dayInter-day
Measured concentration (ng/mL)Accuracy (RE, %)Precision (RSD, %)Measured concentration (ng/mL)Accuracy (RE, %)Precision (RSD, %)

rhein11.00±0.010.51.20.99±0.01-1.01.0
1010.16±0.521.65.110.04±0.340.53.4
100106.60±1.526.61.4101.83±4.741.84.7
emodin22.01±0.100.34.92.00±0.050.12.7
2021.72±0.578.62.620.47±1.232.36.0
200208.21±1.714.10.8201.43±8.990.74.5
stilbene glycoside21.99±0.06-0.43.02.05±0.032.31.6
2020.17±0.760.83.819.91±0.73-0.53.7
200192.33±2.26-3.81.2192.80±6.57-3.63.4
gallic acid21.96±0.05-2.02.62.06±0.053.12.4
2020.00±0.310.11.620.27±0.611.43.0
200186.32±1.66-6.80.9188.68±3.27-5.71.7
ononin21.96±0.04-1.92.01.95±0.03-2.61.4
2020.59±0.883.04.319.62±1.09-1.95.6
200208.21±1.714.10.8202.11±5.921.12.9
verbascoside10.92±0.01-7.81.50.96±0.03-3.93.6
109.82±0.36-1.83.79.66±0.13-3.41.4
100102.66±2.892.72.8102.03±3.012.03.0
liquiritin109.45±0.08-5.50.89.89±0.49-1.14.9
100110.26±3.4410.33.1109.58±2.859.62.6
10001015.89±23.421.62.3990.69±29.65-0.93.0
schisandrin22.00±0.040.22.01.89±0.06-5.43.4
2021.49±0.507.52.320.63±0.703.23.4
200199.93±2.23-0.11.1197.48±3.11-1.31.6
liquiritigenin10.86±0.01-14.01.40.93±0.08-6.58.5
1010.37±0.963.79.39.41±0.50-5.95.3
100106.60±1.526.61.498.95±7.06-1.17.1
glycyrrhizic acid2018.72±0.53-0.12.819.21±0.49-4.02.6
200218.30±1.480.10.7199.59±15.20-0.27.6
20002123.83±59.620.12.81980.71±75.51-1.03.8
isoliquiritigenin10.98±0.02-2.12.10.98±0.01-1.61.5
109.82±0.14-1.81.59.72±0.18-2.81.8
10099.74±0.87-0.30.9100.71±3.080.73.1

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