Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 6

Research Article

Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats

Table 6

Pharmacokinetic parameters of 11 analytes after oral administration of TMYX extract (n=6).

CompoundsTmax1 (h)Tmax2 (h)Cmax1 (ng/mL)Cmax2 (ng/mL)t1/2 (h)Ke (1/h) (h·ng/mL) (h·ng/mL)

rhein0.36±0.3146.3±15.62.84±2.130.56±0.50145.0±52.6152.1±61.3
emodin0.32±0.1488.0±37.54.21±2.630.39±0.28475.5±121.0561.3±192.3
stilbene glycoside0.50±0.3199.1±27.11.99±1.310.45±0.24283.8±189.1297.5±185.3
liquiritin0.50±0.46199.9±120.22.16±1.440.77±0.54637.2±220.2651.1±219.5
ononin0.46±0.1014.4±6.82.85±1.400.37±0.2558.2±20.269.4±28.5
verbascoside0.37±0.1823.4±8.71.53±0.670.56±0.3151.4±29.861.0±29.8
gallic acid0.75±0.6756.9±42.83.01±1.350.27±0.12214.7±136.7238.4±172.8
schisandrin1.00±0.9292.6±53.02.73±1.540.34±0.19410.8±238.9473.4±321.2
liquiritigenin0.20±0.077.20±3.3537.8±24.121.0±15.312.70±7.040.50±0.34314.8±129.8332.6±142.1
glycyrrhizic acid2.13±1.4417.67±10.31351.7±347.4476.1±146.018.19±9.610.05±0.0312743.5±5058.217327.3±10967.3
isoliquiritigenin0.28±0.117.00±2.4541.6±24.224.9±13.513.46±8.330.07±0.04410.0±130.7436.2±154.1

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