Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS

Table 4

Intra- and Interday precision and accuracy of these standard curves.

Name	QC conc.	Intraday			Interday
		Concentration	RSD	Accuracy	Concentration	RSD	Accuracy
	(ng/mL)	(ng/mL)	(%)	(%)	(ng/mL)	(%)	(%)
Aconitine	0.10	0.09 ± 0.01	6.03	91.18 ± 5.49	0.08 ± 0.01	8.12	83.09 ± 6.75
	0.40	0.39 ± 0.01	3.31	98.05 ± 3.24	0.40 ± 0.02	4.06	100.49 ± 4.08
	4.00	4.30 ± 0.30	7.06	107.38 ± 7.58	4.00 ± 0.08	1.98	99.92 ± 1.98
	8.00	8.02 ± 0.36	4.45	100.25 ± 4.46	7.94 ± 0.19	2.35	99.28 ± 2.34
Mesaconitine	0.10	0.11 ± 0.00	2.20	111.64 ± 2.45	0.10 ± 0.02	15.88	100.71 ± 15.99
	0.40	0.40 ± 0.01	3.73	100.26 ± 3.74	0.38 ± 0.03	7.86	95.08 ± 7.47
	4.00	3.96 ± 0.23	5.76	99.08 ± 5.7	3.98 ± 0.24	6.10	99.44 ± 6.06
	8.00	7.93 ± 0.28	3.57	99.07 ± 3.54	7.94 ± 0.25	3.15	99.30 ± 3.13
Hypaconitine	0.10	0.10 ± 0.01	5.79	104.52 ± 6.05	0.11 ± 0.00	3.45	105.48 ± 3.64
	0.40	0.38 ± 0.01	3.39	95.55 ± 3.24	0.39 ± 0.01	3.82	97.76 ± 3.74
	4.00	4.17 ± 0.27	6.36	104.26 ± 6.63	4.06 ± 0.18	4.51	101.58 ± 4.58
	8.00	8.02 ± 0.36	4.45	100.25 ± 4.46	7.94 ± 0.19	2.35	99.28 ± 2.34