Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS

Table 7

Effect of P. ginseng on the pharmacokinetics of aconitine at day 7 after administration.

Aconitine	Control	P. ginseng-low	P. ginseng-middle	P. ginseng-high
(μg/Lh)	40.77 ± 9.71	58 ± 13.02	61.05 ± 12.82	162.98 ± 48.50
(μg/Lh)	46.20 ± 9.57	60.32 ± 12.99	61.49 ± 13.16	228.56 ± 100.03
(h)	10.71 ± 4.78	10.10 ± 3.72	6.14 ± 1.18	26.49 ± 23.27
(h)	2.67 ± 2.91	4.00 ± 3.27	2.11 ± 2.97	1.33 ± 0.41
/F (L/kg)	3345.75 ± 1370.68	2480.3 ± 944.53	1458.36 ± 189.64	1547.04 ± 685.53
/F (L/h/Kg)	225.85 ± 54.74	172.11 ± 35.46	169.57 ± 40.27	51.09 ± 21.00
(μg/L)	3.88 ± 0.92	5.03 ± 3.02	5.79 ± 2.80	11.53 ± 3.49

Note: Compared with the control group, <0.05, <0.01.