Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS

Table 9

Effect of P. ginseng on the pharmacokinetics of hypaconitine at day 7 after administration.

Hypaconitine	Control	P. ginseng-low	P. ginseng-middle	P. ginseng-high
(μg/Lh)	48.12 ± 24.59	65.64 ± 13.14	70.71 ± 7.55	71.75 ± 22.2
(μg/Lh)	60.16 ± 28.03	70.68 ± 8.89	71.49 ± 8.07	77.26 ± 25.15
t1/2z (h)	14.11 ± 5.41	9.70 ± 3.55	6.97 ± 1.77	11.67 ± 4.21
Tmax (h)	2.67 ± 2.91	3.61 ± 3.47	2.53 ± 3.01	1.83 ± 1.29
Vz/F (L/kg)	3881.01 ± 1698.43	2023.85 ± 818.73	1400.22 ± 272.41	2283.28 ± 953.88
CLz/F (L/h/Kg)	204.16 ± 98.97	143.1 ± 15.52	141.34 ± 15.57	139.20 ± 37.51
Cmax (μg/L)	4.63 ± 1.96	4.02 ± 2.01	5.85 ± 2.71	4.87 ± 1.36

Note: Compared with the control group, <0.05, <0.01.