Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes

Figure 4

Type 1 diabetes induced by alloxan and the interference of Baccharis trimera hydroethanolic extract (Bt) in this process. When the diabetes model was induced with alloxan the animals had increased glucose, decreased insulin and body weight. In diabetic groups also found an increase in triacylglycerol, urea, AST and ALT. In the liver, there was an increase in SOD activity and decreased in CAT and GPx activity; there was an increase in GSH and decreased in GSSG. Besides, mRNA-CAT and mRNA-Mn-SOD were increased and mRNA-Zn-SOD and mRNA-GPx were decreased. Increased in carbonyl protein in the liver was also found. These events promote oxidative stress. Baccharis trimera (Bt) promoted a decrease in glycaemia, AST, carbonyl protein, and TBARS, mRNA-CAT, and mRNA-Mn-SOD and also an increase in insulin. AST: aspartate aminotransferase; ALT: alanine aminotransferase; SOD: superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase; GR: glutathione reductase; GSH: reduced glutathione; GSSG: oxidized glutathione; TBARS: thiobarbituric acid reactive substances.