ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells

<div><i>Manilkara zapota </i>leaf methanol extract induces cell apoptosis involved in reactive oxygen species (ROS) production in HeLa cells. The levels of ROS were determined with DCFH-DA staining by flow cytometry after 72 h treatment with<i> Manilkara zapota </i>leaf methanol extract. Values are reported as mean ± SD (n = 3). Value with different superscript letter indicates significant difference between groups by Tukey’s test (<i>P</i> &lt; 0.05).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 7

Figure 7: ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells 

Figure 7 | ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells 