ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells

<div><i>Manilkara zapota </i>leaf methanol extract induced loss of mitochondria membrane potential. HeLa cells were incubated with 12, 24, and 48 <i>μ</i>g/mL of<i> Manilkara zapota </i>leaf methanol extract for 72 h and staining with MitoLite Orange. The fluorescence intensity was measured using NovoCyte Flow Cytometer with NovoExpress software. Values are reported as mean ± SD (n = 3). Value with different superscript letter indicates significant difference between groups by Tukey’s test (<i>P</i> &lt; 0.05).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells 

Figure 8 | ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells 