ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells

<div>mRNA levels of<i> cytochrome c</i>, nuclear factor-kappa B (NF-<i>κ</i>B), and epidermal growth factor receptor (<i>EGFR</i>) in HeLa cells treated with<i> Manilkara zapota </i>leaf methanol extract for 72 h and evaluated using quantitative real-time polymerase chain reaction (PCR). Values are reported as mean ± SD (n = 3). Value with different superscript letter indicates significant difference between groups by Tukey’s test (<i>P </i>&lt; 0.05).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 9

Figure 9: ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells 

Figure 9 | ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells 