A New Strategy to Uncover the Anticancer Mechanism of Chinese Compound Formula by Integrating Systems Pharmacology and Bioinformatics

Figure 5

The genetic alterations and survival analysis related to the 5 overlapping targets (including CDK2, CCND1, TP53, CCNE1, and CCNE2) in SCLC studies embedded in cBio cancer genomics Portal. (The annotations were consistent with those in Figure 4.) (a) Overview of changes in 5 overlapping targets in genomics datasets available in 3 different SCLC studies. (b) OncoPrint (data taken from the U Cologne studies, Nature 2015) [11] based on a query of the 5 overlapping targets). (c) K-M curve between groups with alterations and without alterations.

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