Research Article

A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species

Table 1

List of proteins related to the methylglyoxal degradation superpathway in Leishmania infantum and the sequence homology regarding mammalian proteins. N.C.: not calculated; N.F.: not found.

UniProt IDProtein nameSTRING scoreBLASTp
Homo sapiensMus musculus
valueIdentity % valueIdentity %

A4IBI9Glyoxalase IN.C.3534
A4I2L1Putative methylmalonyl-coenzyme a mutase0,9746262
A4I7A2Putative acetyl-CoA carboxylase0,9463736
A4I399Putative propionyl-CoA carboxylase beta chain0,8676868
A4I398Putative propionyl-CoA carboxylase beta chain0,8675454
A4HUX0Putative 3-methylcrotonyl-CoA carboxylase beta subunit0,8675961
E9AG50Kinase-like protein0,8483938
A4HZ66Metallo-beta-lactamase family-like protein0,6534141
A4I7C0Methylcrotonyl-CoA carboxylase biotinylated subunit protein-like protein0,6424444
A4HRC6Putative carboxylase0,6425252
Q2PYN0Glyoxalase IIN.C.3637
A4I309D-lactate dehydrogenase-like protein0,9493635
A4I1U1Methylmalonyl-CoA epimerase-like protein0,8926160
A4HSD8NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase0,660N.F.N.F.2,939
A4HW95Putative glutathione-S-transferase/glutaredoxin0,6592726
A4I8D6Uncharacterized protein0,6312929
A4I330Obg-like ATPase 10,6315454
A4I2Y9Putative GTP binding protein0,6313435
E9AHF3Glutaredoxin-like protein0,6093334
A4HYU2Putative glutaredoxin0,6092927
A4I342Aldo-keto reductase-like proteinN.C.3637
A4HY37Gamma-glutamylcysteine synthetase0,6234747
A4I8R5Putative d-xylulose reductase0,6114142
E9AG23D-3-phosphoglycerate dehydrogenase-like protein0,5493434
A4IAM3D-isomer specific 2-hydroxyacid dehydrogenase-like protein0,5493232
A4I9V3D-isomer specific 2-hydroxyacid dehydrogenase-protein0,5493234
A4IDE7Putative aldehyde dehydrogenase0,5054646
A4IDU0Aldehyde dehydrogenase0,4933230
A4I5W9Putative aldehyde dehydrogenase0,4933232
A4I1F4Aldehyde dehydrogenase, mitochondrial0,4935252
A4HRT1Putative delta-1-pyrroline-5-carboxylate dehydrogenase0,4935049