GEPSI: A Gene Expression Profile Similarity-Based Identification Method of Bioactive Components in Traditional Chinese Medicine Formula

Table 2

The primary pharmacological action of the top ten small molecule drugs.

Drug	Primary pharmacological action	References
Phenoxybenzamine	Hypertension; mediated peripheral vasodilation; pheochromocytoma	[4–6]
Diethylstilbestrol	Menopausal syndrome; postmenopausal osteoporosis; breast cancer	[7–9]
Anisomycin	Immunosuppression	[10, 11]
Equilin	Postmenopausal osteoporosis	[12]
Digoxigenin	Hypertension; valvular heart disease; cell proliferation inhibition, such as breast cancer, etc.	[13–16]
Resveratrol	Anticancer; immunoregulation	[17–20]
Estradiol	Metastatic breast cancer	[21–23]
Prochlorperazine	Antinausea after chemotherapy	[24, 25]
Genistein	Anticancer; radiation protection; immunoregulation	[26–29]
Thioridazine	Anticancer; antischizophrenia	[30–33]