A Phenolic Fraction from Catharanthus roseus L. Stems Decreases Glycemia and Stimulates Insulin Secretion
Table 3
Blood glucose reduction (%) in diabetic mice due to the administration of the aqueous alkaloid-free extract and its fractions obtained from Catharanthus roseus.
Treatment
Dose
Blood glucose reduction ()
2 h
4 h
6 h
Saline solution
4 mL/kg
12.7 ± 7.64
15.0 ± 6.42
12.5 ± 6.61
Glibenclamide
10 mg/kg
24.0 ± 4.68
37.0 ± 3.61
43.5 ± 5.98
Aqueous alkaloid-free extract
250 mg/kg
26.5 ± 7.61
28.2 ± 7.94
40.6 ± 6.2
Aqueous fraction
250 mg/kg
1.2 ± 6.27
49.2 ± 7.26
51.2 ± 19.3
Organic fraction
250 mg/kg
-22.2 ± 4.19
-0.09 ± 6.32
2.9 ± 9.35
Precipitate
250 mg/kg
2.6 ± 9.35
35.2 ± 4.48
64.5 ± 1.71
Values are the mean percentage of blood glucose reduction (±S.E.M.). indicates significant differences compared with fasting glycemia (p < 0.05), n=5.
