Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation

Table 3

Differentially expressed genes that positively regulate chondrocyte proliferation.

Gene name	Blank; (FPKM)	GZZSZTW; (FPKM)	log2 fold change (GZZSZTW /Blank)	p value
Tumor necrosis factor alpha-induced protein 2 (Tnfaip2)	37.69	129.86	1.78	0
Chitinase-3-like protein 1 (Chi3l1)	40.76	122.14	1.58	1.55E-121
Tumor necrosis factor (Tnf)	9.18	24.24	1.40	7.31E-21
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (Pfkfb3)	9.68	22.87	1.24	1.76E-51
Transcription factor SOX-8 (Sox8)	2.99	15.93	2.41	1.25E-50
Protein jagged-1 (Jag1)	6.29	13.38	1.09	3.80E-27
Transcription factor MafB (Mafb)	5.08	10.76	1.08	6.05E-14
Platelet-activating factor acetylhydrolase (Pla2g7)	4.33	9.88	1.19	1.02E-08
Heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1)	0.01	6.60	9.37	1.87E-21
Transcription factor E2F3 (E2f3)	2.47	5.44	1.14	2.88E-11