Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: A Review

Figure 1

Probable immunomodulation mechanism of action of mushroom glucans. They utilize Dectin-1, CR3, and TLR-2 leading to activation and signal transduction of T lymphocytes, MAPK, and NF-kB, in turn leading to chemokine production and activation and stimulation of lymphocytes, macrophages, and NK cells, which results in inhibition of cancer proliferation through either direct toxicity, apoptosis, and cancer cell cycle arrest or hindering angiogenesis and metastasis of cancer cells.