The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway

Figure 8

Proposed scheme of GJ extracts suppressed CIR-induced apoptosis via PI3K/Akt signaling pathway. GJ extracts pretreatment significantly improved the neurological deficits, decreased infarct volume, downregulated the level of cleaved caspase-3, and upregulated the levels of Bcl-2/ Bax, which could be caused by promoting PI3K expression and phosphorylation with Akt.