Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells

Figure 4

Immunohistochemical analysis of pancreatic tissues of rats for the expression of actin, Ki-67, and transforming growth factor beta1 (TGF-β1) on the 2nd, 5th, and 8th days after cerulein-induced AP was induced. Evaluation of photomicrographs of a representative section of pancreatic tissue obtained from either a AP rat or a rhubarb treated rat indicated that there were many more Ki-67, actin, and TGF-β1–positive nuclei or matrix detected in pancreatic tissue of rats treated with rhubarb. Arrows indicate Ki-67–positive nuclei of acinar cells. Original magnification: ×200.