Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study
Table 2
Brain regions showing abnormal activities by acupuncture stimulation (compared with the resting state) at real or sham acupuncture points in AD patients.
Group
Brain Regions
Activity
BA
Side
Cluster Size
MNI coordinates
T value
x
y
z
AD with real acupuncture point stimulation
Frontal_Inf_Oper
+
/
R
18
66
15
21
5.54
Cerebellum_Crus2
+
/
L
182
-15
-90
-33
4.69
Cerebellum_Crus1
+
/
R
34
27
-90
-27
4.87
Frontal_Inf_Orb
+
47
R
28
57
24
-6
4.55
Lateral Globus Pallidus
+
/
L
18
-21
-12
3
4.23
Rolandic_Oper
+
/
L
98
-57
9
0
4.09
Parietal_Sup
+
/
L
18
-30
-72
57
3.43
Supramarginal
+
/
L
20
-60
-24
21
3.40
Temporal_Mid
+
/
R
21
60
-60
0
3.15
Cuneus
-
/
R
128
18
-69
27
-2.65
Pallidum
-
/
R
38
21
0
-6
-2.66
Rectus
-
/
L
45
-12
30
-18
-2.67
Cerebellum_4_5
-
/
L
38
-12
-36
-12
-2.68
Occipital_Inf
-
/
R
47
42
-72
-9
-2.70
Putamen
-
/
L
24
-6
9
-6
-2.69
AD with sham acupuncture point stimulation
Cerebellum_4_5
+
/
R
50
9
-57
-18
4.50
Rolandic_Oper
+
44
R
32
60
6
9
4.17
Cerebellum_4_5
+
/
L
22
-15
-33
-24
4.21
Cerebellum_Crus2
+
/
L
18
-9
-87
-33
4.19
Parietal_Inf
+
/
L
19
-45
-48
39
3.95
Cerebellum_6
+
/
L
18
-15
-63
-18
3.78
Cerebellum_4_5
+
/
R
50
9
-57
-18
4.50
The peak voxel for each cluster and the corresponding name of the anatomical region are given. “+” represents increased activities during the period of acupuncture stimulation from resting state, whereas “-” represents decreased ones. BA: Brodmann area. The maximum P value for voxels was 0.01 and all surviving voxels had an adjusted P value <0.05.
