Table 2: Brain regions showing abnormal activities by acupuncture stimulation (compared with the resting state) at real or sham acupuncture points in AD patients.

GroupBrain RegionsActivityBASideCluster SizeMNI coordinatesT value
xyz

AD with real acupuncture point stimulationFrontal_Inf_Oper+/R186615215.54
Cerebellum_Crus2+/L182-15-90-334.69
Cerebellum_Crus1+/R3427-90-274.87
Frontal_Inf_Orb+47R285724-64.55
Lateral Globus Pallidus+/L18-21-1234.23
Rolandic_Oper+/L98-57904.09
Parietal_Sup+/L18-30-72573.43
Supramarginal+/L20-60-24213.40
Temporal_Mid+/R2160-6003.15
Cuneus-/R12818-6927-2.65
Pallidum-/R38210-6-2.66
Rectus-/L45-1230-18-2.67
Cerebellum_4_5-/L38-12-36-12-2.68
Occipital_Inf-/R4742-72-9-2.70
Putamen-/L24-69-6-2.69

AD with sham acupuncture point stimulationCerebellum_4_5+/R509-57-184.50
Rolandic_Oper+44R3260694.17
Cerebellum_4_5+/L22-15-33-244.21
Cerebellum_Crus2+/L18-9-87-334.19
Parietal_Inf+/L19-45-48393.95
Cerebellum_6+/L18-15-63-183.78
Cerebellum_4_5+/R509-57-184.50

The peak voxel for each cluster and the corresponding name of the anatomical region are given. “+” represents increased activities during the period of acupuncture stimulation from resting state, whereas “-” represents decreased ones. BA: Brodmann area. The maximum P value for voxels was 0.01 and all surviving voxels had an adjusted P value <0.05.