Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study

Table 4

Brain regions showing abnormal activities by acupuncture stimulation (compared with the resting state) at real acupuncture points in healthy controls.

Brain regions	Activity	BA	Side	Cluster size	MNI coordinates			T -value
					x	y	z
Temporal_Pole_Sup	+	22	R	201	63	3	-3	7.04
Parietal_Inf	+	/	L	368	-42	-57	57	5.95
Occipital_Mid	+	/	L	89	-33	-81	36	5.80
Postcentral	+	/	R	26	36	-42	66	5.44
Temporal_Sup	+	/	R	28	69	-12	12	5.18
Occipital_Inf	+	/	L	24	-48	-66	-18	4.88
Parietal_Sup	+	/	R	96	24	-66	51	4.83
Precentral	+	/	R	24	33	-24	63	4.05
Supramarginal	+	40	R	36	57	-30	36	3.34
Cerebelum_6	+	/	R	77	18	-78	-21	3.88

The peak voxel for each cluster and the corresponding name of the anatomical region are given. “+” represents increased activities during the period of acupuncture stimulation from resting state. BA: Brodmann area. The maximum P value for voxels was 0.01 and all surviving voxels had an adjusted P value <0.05.