Research Article

Manilkara zapota (L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways

Figure 3

Close-up view of morphological changes in HepG2 cells after treatment with Manilkara zapota leaf water extract (magnification 400 ×) viewed under an inverted light microscope. The cells showed the apoptosis characteristics such as cellular shrinkage (CS), apoptotic bodies (AB), nuclear fragmentation (NF), and membrane blebbing (MB) (magnification 400 ×).