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Evidence-Based Complementary and Alternative Medicine
Volume 2018 (2018), Article ID 7827565, 9 pages
Research Article

Advanced Effect of Moringa oleifera Bioconversion by Rhizopus oligosporus on the Treatment of Atopic Dermatitis: Preliminary Study

1Division of Integrated Biotechnology, Joongbu University, Chungnam 32713, Republic of Korea
2Factorial Research Center, Inc., Seoul 06103, Republic of Korea
3Laboratory of Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea

Correspondence should be addressed to Tae-ho Chung

Received 15 November 2017; Accepted 19 December 2017; Published 17 January 2018

Academic Editor: Victor Kuete

Copyright © 2018 Sang-sun Hur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study was conducted to determine if topical application of Moringa oleifera extracts and its bioconversion product fermented by Rhizopus oligosporus has therapeutic properties enhancement for treatment of atopic dermatitis. Rhizopus oligosporus (KCCM 11232P) was used to ferment Moringa leaves’ extracts in this study. Comparison of organic acids and flavonols in Moringa simple extracts and their fermented product by HPLC analysis revealed that concentration of organic acids and flavonols of bioconversion product was lower than that of hot water extracts. The fermentation process is used as a nutrient for isolation of each component by microorganisms and growth of microorganisms. The results demonstrated that MF extracts effectively reduced clinical features based on macrography, scratching count, and severity scores, as well as model’s serum IgE level, including histopathological analyses.