“Diabetes and Metabolism Disorders Medicinal Plants: A Glance at the Past and a Look to the Future 2018”: Antihyperglycemic Activity of Hamelia patens Jacq. Extracts

Table 6

Kidney and liver profile of experimental rats.

Sample	SCr (mg/dL)	SUr (mg/dL)	BUN (mg/dL)	AlT (mg/dL)	AsT (µU/mL)
HC	1.20 ± 0.03	47.83 ± 15.20	23.94 ± 6.50	65.33 ± 21.72	156.20 ± 60.50
DC	1.05 ± 0.02	82.50 ± 24.69^±	38.53 ± 11.49	99.33 ± 26.27	208.50 ± 93.26
DCV	0.75 ± 0.01	76.00 ± 27.13	32.08 ± 16.24	61.33 ± 13.20	188.80 ± 81.49
Metformin	0.74 ± 0.02	34.50 ± 10.63^▪	20.53 ± 5.04^▪	65.50 ± 12.22	145.40 ± 26.60
Acarbose	0.83 ± 0.31	48.33 ± 1.53	22.67 ± 1.16	59.50 ± 14.57	136.00 ± 36.17
CME 150	0.63 ± 0.02	31.25 ± 1.71^▪▪▪	14.55 ± 0.81^▪	73.25 ± 24.68	138.00 ± 22.07
CME 75	0.90 ± 0.10	43.00 ± 3.61^▪	20.07 ± 1.65	69.67 ± 11.15	139.30 ± 31.18
CME 35	1.37 ± 0.38	54.33 ± 7.52	26.50 ± 3.66	73.25 ± 14.06	157.80 ± 28.49
FME 150	0.67 ± 0.05	31.50 ± 4.07^▪▪▪	14.68 ± 2.39^▪▪	45.50 ± 5.07^▪	141.00 ± 36.40
FME 75	1.20 ± 0.32	56.00 ± 5.77	24.68 ± 4.02	76.25 ± 19.28	136.30 ± 22.29
FME 35	1.10 ± 0.14	47.00 ± 10.86^▪	21.93 ± 5.07	76.75 ± 26.04	134.00 ± 31.23

(SCr) serum creatinine; (SUr) serum urea; (BUN) blood urea nitrogen; (AlT) alanine aminotransferase; (AsT) aspartate aminotransferase; HC: healthy control; DC: diabetic control; DCV: diabetic control vehicle; CME 150: crude methanolic extract at a concentration of 150 mg/kg; CME 75: crude methanolic extract at a concentration of 75 mg/kg; CME 35: crude methanolic extract at a concentration of 35 mg/kg; FME 150: fractional methanolic extract at a concentration of 150 mg/kg; FME 75: fractional methanolic extract at a concentration of 75 mg/kg; FME 35: fractional methanolic extract at a concentration of 35 mg/kg. For the corresponding mean ± SD, ^±P < 0.05 compared to health control, ^▪P < 0.05 compared to the diabetic control, ^▪▪P < 0.05 compared to the diabetic control, and ^▪▪▪P < 0.05 compared to the diabetic control.