Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 2

Research Article

Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

Table 2

Breast cancer chemopreventive activity of Abyssinone V-4’ methyl ether after 28 days of treatment.

ItemsControlDMBADMBA + AVME 10

Number of mice with tumours/total rats0/63/51/5
Localized tumor incidence (%)0 60 20
Average tumor weight (g/kg)-1.04 ± 03.40.48 ± 0.92
% Inhibition related to tumor weight--53.84
Total tumor burden (g)03.921.67
% Inhibition related to tumor burden--57.39
Volume (cm3)-15.32 ± 3.016.8 ± 0.5

NOR = normal mice treated with distilled water; DMBA = negative control treated with water; DMBA + AVME 10 = animals treated with the Abyssinone V-4’ methyl etherat the dose of 10 mg/kg. All groups except the normal group (control) received an intragastric dose of DMBA at the dose of 100 mg/kg. Data are represented as mean ± SD (n = 5). p < 0.01 and p < 0.001 as compared to negative control; < 0.001 as compared to normal group.