Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 4

Research Article

Abyssinone V-4’ Methyl Ether Isolated from Erythrina droogmansiana (Leguminosae) Inhibits Cell Growth and Mammary Glands Hyperplasia Induced in Swiss Mice by the 7,12-Dimethylbenz(a)anthracene

Table 4

Effects of Abyssinone V-4’ methyl etheron some biochemical and hematological parameters following 28 days of treatment.

ItemControlDMBADMBA + AVME 10

Biochemical parameters
AST37.2 ± 1.2642.6 ± 2.1328.6 ± 1.78
Creatinine (g/L)0.8 ± 0.061.3 ± 0.100.36 ± 0.08

Hematological parameters
WBC (×103µL−1)7.42 ± 2.677.4 ± 2.488.7 ± 0.72
Lymphocytes (%)61.1 ± 4.3257.11 ± 4.9164.5 ± 5.69
Monocytes (%)11.4 ± 3.311.2 ± 0.0412.67 ± 2.08
Granulocytes (%)25.1 ± 5.532.1 ± 4.5923.23 ± 4.28
Hemoglobin171.1 ± 6.99138.2 ± 9.35151.66 ± 16.17
RBC (×103µL−1)9.2 ± 0.0518.48 ± 0.359.13 ± 1.08
Platelets (×103µL−1)453 ± 10.42959.2 ± 11.07833.33 ± 294.65

Control = normal mice treated with distilled water; DMBA = negative control treated with distilled water; DMBA + AVME 10 = animals treated with the Abyssinone V-4’ methyl etherat the dose of 10 mg/kg. All groups except the normal group (control) received an intragastric dose of DMBA at the dose of 100 mg/kg. Data are represented as mean ± SD (n = 5). p < 0.05. p < 0.01 as compared to negative control; < 0.05 and < 0.01 as compared to normal group.