“The Therapy of Elimination First” for Early Acute Mastitis: A Systematic Review and Meta-Analysis

Table 2

Treatments used in the included studies.

Study	Interventions		Suppliers of the TCM	Therapeutic principle of the TCM	Main outcomes	Evaluation methods
	Experimental group	Control group
Liu and Ge, 2009	Self-made mammary abscess eliminating carbuncle decoction	Penicillin	The Third Affiliated Hospital of Luohe Medical College	Heat-clearing and detoxifying, eliminating carbuncle, and resolving masses	Curative rate, pain relief time, mass reduction time, and cure time	Clinical symptoms and physical sign, mass integral
Chen and Xiao, 2011	GuaLouNiuBang decoction	Cefadroxil or ceftriaxone	Xiamen traditional Chinese Medicine Hospital of Fujian Province	Relieving the depressed liver, heat-clearing, and resolving masses	Total effective rate, blood routine	The integral of clinical symptom and physical sign
Zhang, 2006	HuaHong eliminating carbuncle powder	Penicillin + ampicillin	Shandong Zouping hospital of Traditional Chinese Medicine	Clots absorption and dredging collaterals, eliminating carbuncle, and resolving masses	Total effective rate, blood routine	Clinical symptoms and physical sign, mass integral
Wang and Yin, 2004	Self-made detoxification and resolving masses decoction	Penicillin + ampicillin	Binzhou institution hospital	Heat-clearing and detoxifying, soothing liver, and regulating stomach	Total effective rate, blood routine	Clinical symptoms and physical sign, mass integral
Wang and Liu, 2014	Self-made mammary abscess formula 1	Cefoxitin	Tianjin Hospital of Integrated Traditional Chinese and Western Medicine	Heat-clearing and detoxifying, soothing liver, and lactogenesis	Total effective rate, blood routine	Clinical symptoms and physical sign, mass integral
Yang, 2009	Soothing liver and lactogenesis decoction	Cefuroxime	Shanghai Hospital of Traditional Chinese Medicine	Soothing liver and clearing stomach, lactogenesis, and resolving masses	Total effective rate, blood routine, duration of treatment, and lactation situation	Clinical symptoms and physical sign, mass integral
Liang and Lou, 2015	YangHe decoction	Penicillin	Zhejiang General Hospital, Zhejiang University of Traditional Chinese Medicine	Warming Yang, and dredging collaterals, and resolving hard lump	Total effective rate, curative rate, WBC, neutrophils percentage, and CRP	Lou’s assessment quantitative integral tables of the; curative effect for breast carbuncle
Liu, 2009	Disinfectant soup	Cefoperazone sulbactam	Beijing Electrical Hospital	Heat-clearing and detoxifying, lactogenesis, and eliminating carbuncle	Total effective rate, OR, and NNT	Clinical symptoms and physical sign, mass integral
Tang, 2009	ZhiDanxiaoru decoction	Cefotaxime	Hebei Huailai Hospital of Traditional Chinese Medicine	Eliminating heat, purging fire, cooling blood, and detumescence	Total effective rate, curative rate, recurrence rate, cure, and effective time required for treatment	Clinical symptoms and physical sign, mass integral
Hu, 2012	Modified herbal decoction	Penicillin	Zhejiang Yongkang Maternity and Child Care Hospital	Heat-clearing and detoxifying, resolving masses, and dredging collaterals	Total effective rate, recovery time for temperature, and pain relief time	Clinical symptoms and physical sign, mass integral
Fan, 2010	Self-made PuXia decoction	Penicillin	The Second People’s Hospital of Kunshan	Heat-clearing and detoxifying, detumescence, and resolving masses	Total effective rate	Clinical symptoms and physical sign, mass integral
Lin and Wang, 2007	Single Taraxacum decoction	Cephradine	Qingdao Central Hospital	Heat-clearing and detoxifying, antiphlogistic, and clots absorption	Total effective rate, average effective time	Clinical symptoms and physical sign, mass integral
Hou and Lv, 2015	GuaLouNiuBang decoction	Cefazolin pentahydrate	Chongqing Hospital of Traditional Chinese Medicine	Detumescence and lactogenesis, soothing liver, and clearing stomach	Total effective rate	Clinical symptoms and physical sign, mass integral
Mao, 1998	YangHe decoction	Cephradine	Zhejiang Hangzhou Gongshu Hospital of Integrated Traditional Chinese and Western Medicine	Warming Yang and dredging collaterals	Total effective rate	Mass integral
Cai and Shen, 2016	GuaLouNiuBang decoction	Penicillin	Minhang Branch of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine	Heat-clearing and detoxifying, lactogenesis, and resolving masses	Total effective rate, fever clearance time, pain relief time, and resolving mass time	Clinical symptoms and physical sign, mass integral
Qu et al., 2016	Self-made lactogenesis and resolving masses decoction	Penicillin	Zhejiang Lishui hospital of Traditional Chinese Medicine	Heat-clearing and detoxifying, resolving masses, and Eliminating carbuncle	Total effective rate	Clinical symptoms and physical sign, mass integral

WBC: white blood cell; CRP: C-reactive protein; OR: odds ratio; NNT: number needed to treat.